Transforming Cardiac Care
Plaque-Informed Ischemia: A New Paradigm for Vessel-Specific Risk Assessment
Webinar with Live Q&A — May 14, 2026 - 7pm EDT
Predicting risk with anatomy and physiology
Join interventional cardiologist Neerav Sheth, MD, for an in-depth discussion on how the new paradigm of ischemia assessment now utilizes coronary plaque volume and morphology as critical measures of risk stratification.
This session will examine findings from multi-center clinical trials demonstrating the efficacy of coronary computed tomography angiography (CCTA) combined with plaque-based ischemia analysis. Attendees will also learn how Cleerly ISCHEMIA, an AI-enabled and non-invasive CCTA analysis, integrates information about coronary plaque, anatomy and physiology to diagnose the likelihood of vessel-specific ischemia.
Additionally, Dr. Sheth will share real-world case studies and discuss how plaque-informed ischemia analysis can support provider decision-making at multiple points along the care pathway.
Dr. Sheth’s presentation will conclude with a Q&A session, open to all attendees.
Our key panelists

Neerav Sheth MD, MBA, FACC, FSCAI
Interventional Cardiologist, Level III Cardiac Reader, Cardiology Consultants of Philadelphia
Dr. Sheth is an interventional cardiologist with a focus in complex coronary, peripheral arterial and venous diseases. He has an additional interest in multi-modality imaging. He chairs committees for the Pennsylvania Board of Medicine and the ACC.

Tony DeFrance, MD, FSCCT
VP of Clinical Affairs, Cleerly
Dr. DeFrance is an interventional cardiologist, cardiovascular imaging expert and medical educator focused on transforming how physicians detect and manage coronary artery disease. He has trained over 3,000 physicians around the world in CCTA interpretation and plaque-based management and previously served as clinical faculty at Stanford.
May 14, 2026 @ 7PM EDT
REGISTER NOW for Plaque-Informed Ischemia: A New Paradigm for Vessel-Specific Risk Assessment
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Discussion topics
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The Role of Plaque Morphology
Learn about the role of nonobstructive, soft plaque in ischemia risk assessment.
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Cleerly ISCHEMIA Validation
Understand how Cleerly ISCHEMIA was validated against the gold standard, FFR.
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Clinical Insights
Discover how plaque-informed analyses can aid decision-making before intervention.
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Case Studies
See real-world examples with patient outcomes and example reporting from Cleerly ISCHEMIA.
Disclaimer: Dr. Sheth has been compensated by Cleerly for his participation in this program.
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Cleerly's Transforming Cardiac Care webinar series is open to any cardiologist, radiologist, or other healthcare professional with an interest in breakthrough medtech for heart disease and prevention.
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