Publications

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Post hoc analysis of CREDENCE and PACIFIC-1

Post Hoc Analysis of CREDENCE and PACIFIC-1

Development and Validation of a Quantitative Coronary CT Angiography Model for Diagnosis of Vessel-Specific Coronary Ischemia

Named a 2024 top 10 paper in ischaemic heart disease by European Heart Journal.

Nurmohamed, et al.
JACC: Cardiovascular Imaging
Volume 17, Issue 8, August 2024

This newly developed coronary CTA-based ischemia model using coronary atherosclerosis and vascular morphology characteristics accurately diagnoses coronary ischemia by invasive FFR and provides robust prognostic utility for MACE beyond presence of stenosis.

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CERTAIN Multicenter Clinical Trial

CERTAIN

Impact of Atherosclerosis Imaging-Quantitative Computed Tomography on Diagnostic Certainty, Downstream Testing, Coronary Revascularization, and Medical Therapy: The CERTAIN Study

Nurmohamed, et al.
European Heart Journal – Cardiovascular Imaging
Volume 25, Issue 6, June 2024

The use of AI-QCT improves diagnostic certainty and may result in reduced downstream need for non-invasive testing and increased rates of preventive medical therapy.

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CREDENCE Trial Substudy

A CREDENCE Trial Substudy

AI Evaluation of Stenosis on Coronary CT Angiography, Comparison With Quantitative Coronary Angiography and Fractional Flow Reserve

Griffin, et al.
JACC: Cardiovascular Imaging
Volume 16, Issue 2, February 2023

A novel AI-based evaluation of coronary CTA enables rapid and accurate identification and exclusion of high-grade stenosis and with close agreement to blinded, core lab–interpreted quantitative coronary angiography.

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AI-QCT prognostic value for MACE

AI-Guided Quantitative Plaque Staging Predicts Long-Term Cardiovascular Outcomes in Patients at Risk for Atherosclerotic CVD

Nurmohamed, et al.
JACC: Cardiovascular Imaging
Volume 17, Issue 3, March 2024

Through 10-year follow-up, AI-QCT plaque staging showed important prognostic value for MACE and showed additional discriminatory value over clinical risk factors, CACS, and manual guideline-recommended CCTA assessment.

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CCTA Based Atherosclerosis Treatment Algorithms

Integrating Coronary Atherosclerosis Burden and Progression with Coronary Artery Disease Risk Factors to Guide Therapeutic Decision Making

Freeman, et al.
The American Journal of Medicine
Volume 136, Issue 3

The American College of Cardiology Innovations in Prevention Working Group introduce the Atherosclerosis Treatment Algorithms that personalize medical interventions based upon atherosclerosis findings from coronary computed tomography angiography (CTA) and cardiovascular risk factors.

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Prognostic Value of AI-Based Quantitative Coronary CT Versus Human Reader–Based Visual Assessment: Results from the CONFIRM2 Registry
Prognosis

Prognostic Value of AI-Based Quantitative Coronary CT Versus Human Reader–Based Visual Assessment: Results from the CONFIRM2 Registry

Alexander van Rosendael et al.
JACC CVI

Prognostic value of a CCTA-derived ischemia algorithm: comparison against hybrid CCTA/PET imaging
Prognosis

Prognostic value of a CCTA-derived ischemia algorithm: comparison against hybrid CCTA/PET imaging

Teemu Maaniitty et al.
JAHA

Stenosis degree and plaque burden differ between the major epicardial coronary arteries supplying ischemic territories
Mechanisms of CAD

Stenosis degree and plaque burden differ between the major epicardial coronary arteries supplying ischemic territories

Tanja Kero et al.
Journal of Nuclear Cardiology

Sex differences in plaque burden and outcomes in symptomatic patientswith suspected coronary artery disease
Mechanisms of CAD

Sex differences in plaque burden and outcomes in symptomatic patientswith suspected coronary artery disease

David Molnar et al.
IJC

First myocardial infarction: risk factors, symptoms, and medical therapy
Mechanisms of CAD

First myocardial infarction: risk factors, symptoms, and medical therapy

Nick Nurmohamed et al.
European Heart Journal

Coronary artery stenosis, plaque burden and severity of myocardial ischemia
Mechanisms of CAD

Coronary artery stenosis, plaque burden and severity of myocardial ischemia

Tanja Kero et al.
EHJ IMP

Artificial intelligence-guided quantitative coronary CT angiography (AI-QCT) automated detection and occlusion length estimation of chronic total occlusions.
Mechanisms of CAD

Artificial intelligence-guided quantitative coronary CT angiography (AI-QCT) automated detection and occlusion length estimation of chronic total occlusions.

Pedro Carvalho et al.
JCCT

Incremental value of a CCTA-derived AI-based ischemia algorithm over standard CCTA interpretation of predicting myocardial ischemia in patients with suspected coronary artery disease
Diagnostic Performance

Incremental value of a CCTA-derived AI-based ischemia algorithm over standard CCTA interpretation of predicting myocardial ischemia in patients with suspected coronary artery disease

Takeru Nabeta et al.
JCCT

Coronary Plaque Volume in an Asymptomatic Population: Miami Heart Study at Baptist Health South Florida
Changes in Patient Management

Coronary Plaque Volume in an Asymptomatic Population: Miami Heart Study at Baptist Health South Florida

Keishi Ichikawa et al.
JACC CVI

Artificial intelligence-guided coronary computed tomography angiography: treatment recommendations versus real-world prescriptions
Changes in Patient Management

Artificial intelligence-guided coronary computed tomography angiography: treatment recommendations versus real-world prescriptions

Sophie Cramer et al.
EJPC

CTA-Derived Plaque Characteristics and Risk of Acute Coronary Syndrome in Patients With Coronary Artery Calcium Score of Zero: Insights From the ICONIC Trial
Prognosis

CTA-Derived Plaque Characteristics and Risk of Acute Coronary Syndrome in Patients With Coronary Artery Calcium Score of Zero: Insights From the ICONIC Trial

Rebecca A Jonas et al.
American Journal of Roentgenology

Factors affecting the performance of a novel artificial intelligence-based coronary computed tomography-derived ischaemia algorithm
Diagnostic Accuracy

Factors affecting the performance of a novel artificial intelligence-based coronary computed tomography-derived ischaemia algorithm

Peerapon Kiatkittikul et al.
European Heart Journal - Cardiovascular Imaging

AI-Quantitative CT Coronary Plaque Features Associate with a Higher Relative Risk in Women: CONFIRM2-Registry;
Prognosis

AI-Quantitative CT Coronary Plaque Features Associate with a Higher Relative Risk in Women: CONFIRM2-Registry;

Gudrun Feuchtner et al.
Circulation: Cardiovascular Imaging

CCTA-Derived Coronary Plaque Burden Offers Enhanced Prognostic Value Over CAC Scoring In Suspected CAD Patients
Prognosis

CCTA-Derived Coronary Plaque Burden Offers Enhanced Prognostic Value Over CAC Scoring In Suspected CAD Patients

Jorge Dahdal et al.
European Heart Journal - Cardiovascular Imaging

Derivation and Validation of an Artificial Intelligence-Based Plaque Burden Safety Cut-Off for Long-Term Acute Coronary Syndrome from Coronary Computed Tomography Angiography
Prognosis

Derivation and Validation of an Artificial Intelligence-Based Plaque Burden Safety Cut-Off for Long-Term Acute Coronary Syndrome from Coronary Computed Tomography Angiography

Sarah Bär et al.
European Heart Journal - Cardiovascular Imaging

Plaque burden improves the detection of ischemic CAD over stenosis from coronarycomputed tomography angiography
Prognosis

Plaque burden improves the detection of ischemic CAD over stenosis from coronarycomputed tomography angiography

Tanja Kero et al.
International Journal of Cardiovascular Imaging

Artificial intelligence quantification and experienced reader computed tomography analysis for differentiating normal from minimally and mildly diseased coronary arteries: an early real-world compatibility study
Diagnostic Performance

Artificial intelligence quantification and experienced reader computed tomography analysis for differentiating normal from minimally and mildly diseased coronary arteries: an early real-world compatibility study

Amr Idris, Victor Cheng et al.
International Journal of Cardiovascular Imaging

Diagnostic accuracy in coronary CT angiography analysis: artificial intelligence versus human assessment
Diagnostic Accuracy

Diagnostic accuracy in coronary CT angiography analysis: artificial intelligence versus human assessment

Bernardo et al.
Open Heart

Lipoprotein(a) and coronary artery disease burden in patients with diabetes
Mechanisms of CAD

Lipoprotein(a) and coronary artery disease burden in patients with diabetes

Salvas JP et al.
JCCT

Artificial Intelligence-Enhanced Coronary Computed Tomography Angiography for Chronic Coronary Total Occlusion Percutaneous Coronary Intervention
Mechanisms of CAD

Artificial Intelligence-Enhanced Coronary Computed Tomography Angiography for Chronic Coronary Total Occlusion Percutaneous Coronary Intervention

Pedro Carvalho et al.
JACC Imag

First comparison between artificial intelligence-guided coronary computed tomography angiography versus single-photon emission computed tomography testing for ischemia in clinical practice
Diagnostic Accuracy

First comparison between artificial intelligence-guided coronary computed tomography angiography versus single-photon emission computed tomography testing for ischemia in clinical practice

Geoffrey Cho et al.
Coron Art Dis

Artificial Intelligence-Enhanced Coronary Computed Tomography Angiography for Chronic Coronary Total Occlusion Percutaneous Coronary Intervention
Clinical Utility

Artificial Intelligence-Enhanced Coronary Computed Tomography Angiography for Chronic Coronary Total Occlusion Percutaneous Coronary Intervention

Pedro E.P. Carvolho et al.
JACC: Cardiovascular Interventions

Atherosclerosis Quantification and Cardiovascular Risk: The ISCHEMIA Trial
Clinical Utility

Atherosclerosis Quantification and Cardiovascular Risk: The ISCHEMIA Trial

Nick Nurmohamed et al.
EHJ

Polygenic Risk Is Associated With Long-Term Coronary Plaque Progression and High-Risk Plaque
Mechanisms of CAD

Polygenic Risk Is Associated With Long-Term Coronary Plaque Progression and High-Risk Plaque

Nick Nurmohamed et al.
JACC CV Imaging

Location-Specific Prognostic Significance of Plaque Burden, Stenosis, and Plaque Morphology in Coronary Artery Disease
Prognosis

Location-Specific Prognostic Significance of Plaque Burden, Stenosis, and Plaque Morphology in Coronary Artery Disease

Ruurt Jukema et al.
EHJ - Cardiovascular Imaging

Lipoprotein(a) and Long-Term Plaque Progression, Low-Density Plaque, and Pericoronary Inflammation
Mechanisms of CAD

Lipoprotein(a) and Long-Term Plaque Progression, Low-Density Plaque, and Pericoronary Inflammation

Nick Nurmohamed et al.
JAMA Cardiology

Performance of an Artificial Intelligence-Guided Quantitative Coronary Computed Tomography Algorithm for Predicting Myocardial Ischemia in Real-World Practice
Diagnostic Performance

Performance of an Artificial Intelligence-Guided Quantitative Coronary Computed Tomography Algorithm for Predicting Myocardial Ischemia in Real-World Practice

Ron Karlsberg et al.
IJC Heart and Vasculature

Beyond Early LDL Cholesterol Lowering to Prevent Coronary Atherosclerosis in Familial 2 Hypercholesterolemia
Mechanisms of CAD

Beyond Early LDL Cholesterol Lowering to Prevent Coronary Atherosclerosis in Familial 2 Hypercholesterolemia

Shirin Ibrahim et al.
European Journal of Preventive Cardiology

Decreased LDL-Cholesterol Exposure Following ANGPTL3 Inhibition Reduces Coronary Plaque Development in Homozygous Familial Hypercholesterolemia
Mechanisms of CAD

Decreased LDL-Cholesterol Exposure Following ANGPTL3 Inhibition Reduces Coronary Plaque Development in Homozygous Familial Hypercholesterolemia

Willemijn Schonck et al.
JACC CV Imaging

Impact of Atherosclerosis Imaging-Quantitative Computed Tomography on Diagnostic Certainty, Downstream Testing, Coronary Revascularization and Medical Therapy: The CERTAIN Study
Reimbursement

Impact of Atherosclerosis Imaging-Quantitative Computed Tomography on Diagnostic Certainty, Downstream Testing, Coronary Revascularization and Medical Therapy: The CERTAIN Study

Nick Nurmohamed et al.
EHJ Imaging

Atherosclerosis Evaluation and Cardiovascular Risk Estimation Using Coronary Computed Tomography Angiography
Review Paper

Atherosclerosis Evaluation and Cardiovascular Risk Estimation Using Coronary Computed Tomography Angiography

Nick Nurmohamed et al.
EHJ

Assessment of Atherosclerotic Plaque Burden: Comparison of AI-QCT Versus SIS, CAC, Visual and CAD-RADS Stenosis Categories
Diagnostic Performance

Assessment of Atherosclerotic Plaque Burden: Comparison of AI-QCT Versus SIS, CAC, Visual and CAD-RADS Stenosis Categories

Hufsa Khan et al.
International Journal of Cardiovascular Imaging

Prognostic Value of a Novel Artificial Intelligence-Based Coronary Computed Tomography Angiography-Derived Ischemia Algorithm for Patients with Suspected Coronary Artery Disease
Diagnostic Performance

Prognostic Value of a Novel Artificial Intelligence-Based Coronary Computed Tomography Angiography-Derived Ischemia Algorithm for Patients with Suspected Coronary Artery Disease

Sarah Bär et al.
EHJ CV Imaging

Incremental Prognostic Value of a Novel Artificial Intelligence-based CCTA-Derived Ischemia Algorithm Among Patients with Normal and Reduced Myocardial Perfusion
Diagnostic Performance

Incremental Prognostic Value of a Novel Artificial Intelligence-based CCTA-Derived Ischemia Algorithm Among Patients with Normal and Reduced Myocardial Perfusion

Sarah Bär et al.
JCCT

Development and Validation of a Quantitative Coronary CT Angiography Model for Diagnosis of Vessel-Specific Coronary Ischemia
Diagnostic Performance

Development and Validation of a Quantitative Coronary CT Angiography Model for Diagnosis of Vessel-Specific Coronary Ischemia

Nick Nurmohamed et al.
JACC CV Imaging

Artificial Intelligence Coronary Computed Tomography, Coronary Computed Tomography Angiography Using Fractional Flow Reserve, and Physician Visual Interpretation in the Per-Vessel Prediction of Abnormal Invasive Adenosine Fractional Flow Reserve
Diagnostic Performance

Artificial Intelligence Coronary Computed Tomography, Coronary Computed Tomography Angiography Using Fractional Flow Reserve, and Physician Visual Interpretation in the Per-Vessel Prediction of Abnormal Invasive Adenosine Fractional Flow Reserve

Andrew Chiou et al.
EHJ Imaging Methods

The Effect of Tube Voltage on Scan-Rescan Reproducibility of Compositional Plaque Volume: Technical Variability is Not True Biological Change
Diagnostic Performance

The Effect of Tube Voltage on Scan-Rescan Reproducibility of Compositional Plaque Volume: Technical Variability is Not True Biological Change

Francesca Calicchio et al.
EHJ Imaging Methods

Distal-Vessel Fractional Flow Reserve by Computed Tomography to Monitor 1 Epicardial Coronary Artery Disease
Clinical Utility

Distal-Vessel Fractional Flow Reserve by Computed Tomography to Monitor 1 Epicardial Coronary Artery Disease

Chen et al.
EHJ - Cardiovascular Imaging

Diabetes, Atherosclerosis, and Stenosis by AI
Clinical Utility

Diabetes, Atherosclerosis, and Stenosis by AI

Jonas et al.
Diabetes Care

Relationship of Sex to Atherosclerotic Plaque Characteristics by Differing Angiographic Stenosis Severity
Clinical Utility

Relationship of Sex to Atherosclerotic Plaque Characteristics by Differing Angiographic Stenosis Severity

Jonas et al.
American Journal of Cardiology

Impact of Visceral Fat on Coronary Artery Disease as Defined by Quantitative Computed Tomography Angiography
Clinical Utility

Impact of Visceral Fat on Coronary Artery Disease as Defined by Quantitative Computed Tomography Angiography

Karlsberg et al.
Obesity

Comparison of Coronary Artery Calcium and Quantitative Coronary Plaque in Predicting Obstructive Coronary Artery Disease: Subgroup Analysis of CLARIFY Study
Clinical Utility

Comparison of Coronary Artery Calcium and Quantitative Coronary Plaque in Predicting Obstructive Coronary Artery Disease: Subgroup Analysis of CLARIFY Study

Manubolu et al.
Heart International

AI-Guided Quantitative Plaque Staging Predicts Long-Term Cardiovascular Outcomes in Patients at Risk for Atherosclerotic CVD
Clinical Utility

AI-Guided Quantitative Plaque Staging Predicts Long-Term Cardiovascular Outcomes in Patients at Risk for Atherosclerotic CVD

Nurmohamed et al.
JACC CV Imaging

How Early Can Atherosclerosis Be Detected by Coronary CT Angiography? Insights From Quantitative CT Analysis of Serial Scans in the PARADIGM Trial
Diagnostic Performance

How Early Can Atherosclerosis Be Detected by Coronary CT Angiography? Insights From Quantitative CT Analysis of Serial Scans in the PARADIGM Trial

Cardoso et al.
JCCT

Determination of Lipid-Rich Plaques by Artificial Intelligence-Enabled Quantitative Computed Tomography Using Near-infrared Spectroscopy as Reference
Diagnostic Performance

Determination of Lipid-Rich Plaques by Artificial Intelligence-Enabled Quantitative Computed Tomography Using Near-infrared Spectroscopy as Reference

Omori et al.
Atherosclerosis

Rationale and Design of the INVICTUS Registry
Rationale and Design

Rationale and Design of the INVICTUS Registry

Nakanishi et al.
JCCT

Rationale and Design of the CONFIRM2 Study
Rationale and Design

Rationale and Design of the CONFIRM2 Study

van Rosendael et al.
JCCT

Endothelial Shear Stress Computed from Coronary Computed Tomography Angiography: A Direct Comparison to Intravascular Ultrasound
Mechanisms of CAD

Endothelial Shear Stress Computed from Coronary Computed Tomography Angiography: A Direct Comparison to Intravascular Ultrasound

Hakim et al.
JCCT

Atherosclerosis Imaging Quantitative Computed Tomography (AI‐QCT) to Guide Referral to Invasive Coronary Angiography in the Randomized Controlled CONSERVE Trial
Reimbursement

Atherosclerosis Imaging Quantitative Computed Tomography (AI‐QCT) to Guide Referral to Invasive Coronary Angiography in the Randomized Controlled CONSERVE Trial

Kim et al.
Clinical Cardiology

Plaque Progression Differences Between Apixaban and Rivaroxaban in Patients With Atrial Fibrillation Measured With Cardiac Computed Tomography and Plaque Quantification
Clinical Utility

Plaque Progression Differences Between Apixaban and Rivaroxaban in Patients With Atrial Fibrillation Measured With Cardiac Computed Tomography and Plaque Quantification

Aldana-Bitar et al.
American Journal of Therapeutics

Serial Analysis of Coronary Artery Disease Progression by Artificial Intelligence Assisted Coronary Computed Tomography Angiography: Early Clinical Experience
Clinical Utility

Serial Analysis of Coronary Artery Disease Progression by Artificial Intelligence Assisted Coronary Computed Tomography Angiography: Early Clinical Experience

Chen et al.
BMC Cardiovascular Disorders

Quantitative Plaque Analysis with A.I.-Augmented CCTA in End-Stage Renal Disease and Complex CAD
Clinical Utility

Quantitative Plaque Analysis with A.I.-Augmented CCTA in End-Stage Renal Disease and Complex CAD

Cho et al.
Cardiothoracic Imaging

Integrating Coronary Atherosclerosis Burden and Progression with Coronary Artery Disease Risk Factors to Guide Therapeutic Decision Making
Clinical Utility

Integrating Coronary Atherosclerosis Burden and Progression with Coronary Artery Disease Risk Factors to Guide Therapeutic Decision Making

Min et al.
JCCT

AI Evaluation of Stenosis on Coronary CT Angiography, Comparison With Quantitative Coronary Angiography and Fractional Flow Reserve: A CREDENCE Trial Substudy
Diagnostic Performance

AI Evaluation of Stenosis on Coronary CT Angiography, Comparison With Quantitative Coronary Angiography and Fractional Flow Reserve: A CREDENCE Trial Substudy

Griffin et al.
JACC CV Imaging

The Effect of Scan and Patient Parameters on the Diagnostic Performance of AI for Detecting Coronary Stenosis on Coronary CT Angiography
Diagnostic Performance

The Effect of Scan and Patient Parameters on the Diagnostic Performance of AI for Detecting Coronary Stenosis on Coronary CT Angiography

Jonas et al.
Clinical Imaging

Interobserver Variability Among Expert Readers Quantifying Plaque Volume and Plaque Characteristics on Coronary CT Angiography: a CLARIFY Trial Sub-Study
Diagnostic Performance

Interobserver Variability Among Expert Readers Quantifying Plaque Volume and Plaque Characteristics on Coronary CT Angiography: a CLARIFY Trial Sub-Study

Jonas et al.
Clinical Imaging

Coronary CTA With AI-QCT Interpretation: Comparison With Myocardial Perfusion Imaging for Detection of Obstructive Stenosis Using Invasive Angiography as Reference Standard
Diagnostic Performance

Coronary CTA With AI-QCT Interpretation: Comparison With Myocardial Perfusion Imaging for Detection of Obstructive Stenosis Using Invasive Angiography as Reference Standard

Lipkin et al.
American Journal of Roentgenology

Cardiac CT Angiography in Current Practice: An American Society for Preventive Cardiology Clinical Practice Statement
Review Paper

Cardiac CT Angiography in Current Practice: An American Society for Preventive Cardiology Clinical Practice Statement

Budoff et al.
American Journal of Roentgenology

Artificial Intelligence Advancements in the Cardiovascular Imaging of Coronary Atherosclerosis
Review Paper

Artificial Intelligence Advancements in the Cardiovascular Imaging of Coronary Atherosclerosis

Covas et al.
Frontiers in Cardiovascular Medicine

Integrating Coronary Atherosclerosis Burden and Progression with Coronary Artery Disease Risk Factors to Guide Therapeutic Decision Making
Review Paper

Integrating Coronary Atherosclerosis Burden and Progression with Coronary Artery Disease Risk Factors to Guide Therapeutic Decision Making

Freeman et al.
American Journal of Medicine

Relationship of Age, Atherosclerosis and Angiographic Stenosis Using Artificial Intelligence
Clinical Utility

Relationship of Age, Atherosclerosis and Angiographic Stenosis Using Artificial Intelligence

Jonas et al.
Open Heart

CT Evaluation by Artificial Intelligence for Atherosclerosis, Stenosis and Vascular Morphology (CLARIFY): A Multi-Center, International study
Diagnostic Performance

CT Evaluation by Artificial Intelligence for Atherosclerosis, Stenosis and Vascular Morphology (CLARIFY): A Multi-Center, International study

Choi et al
JCCT

The Multidimensionality of Coronary Artery Disease: Combining, Conflating and Changing
Review Paper

The Multidimensionality of Coronary Artery Disease: Combining, Conflating and Changing

Min et al.
JACC: Asia

Quantitative Assessment of Atherosclerotic Plaque, Recent Progress and Current Limitations
Review Paper

Quantitative Assessment of Atherosclerotic Plaque, Recent Progress and Current Limitations

Williams et al.
JCCT